Manuscript disease analysis

Primary manuscript analysis assignment: each student will be required to select a primary article studying a signal transduction pathway from a top-tier journal and provide an in-depth analysis of the article.
https://www.researchgate.net/profile/Janetta-Culvenor/publication/225927644_Amyloid_precursor_protein_processing_and_retinal_pathology_in_mouse_models_of_Alzheimer%27s_disease/links/0f3175315269adad91000000/Amyloid-precursor-protein-processing-and-retinal-pathology-in-mouse-models-of-Alzheimers-disease.pdf
or
https://www.sciencedirect.com/science/article/pii/S0021925819347969

The analysis must include the following components:

1. The complete article reference (Authors, Journal, Volume, Page numbers)

2. A two paragraph description providing the issue being addressed in the article, why it is an important topic, what is generally known about the topic to date (include 4-5 key references), and what question(s) the authors hoped to answer.

3. A list of each technique used in the article that includes technique name, general purpose of the technique, theory behind the technique, and what the authors found using the technique.

Also include a list of controls used for each experiment and for what each is controlling.

4. A list of conclusions made by the authors from each figure.

5. The overall conclusion of the authors.

5. A critique of the article: Which experiments were believable and which were suspect? Would better controls be more appropriate? Doe the authors draw conclusions that are not justified? Would include other experiments to make the data set better?