Biology, Enzymes

You are doing an experiment that requires that 242 (x 106) molecules be produced per minute at a pH of 11.  Which of the following would be the best option to try?

1. Use 16 grams of substrate,
2. Tell your lab supervisor that it is impossible for you to get those results
3. Add twice as much water to make the reaction speed up twice as fast
4. Use 8 grams of substrate and twice as much enzyme as you originally used in the simulation